Abstract Assay of Transposase Accessible Chromatin sequencing (ATAC-seq) is widely
used in studying chromatin biology, but a comprehensive review of the analysis tools has …

LIM-domain proteins are a large family of proteins that are emerging as key molecules in a
wide variety of human cancers. In particular, all members of the human LIM-domain-only …

A prospective study of patients with symptoms of gastroesophageal reflux was undertaken to
determine the prevalence of Barrett's esophagus and reevaluate the diagnostic approach …

Mammalian gene silencing is established through methylation of histones and DNA,
although the order in which these modifications occur remains contentious. Using the …

Non-primate mammalian activity cycles are highly variable across and within taxonomic
groups. In contrast, the order Primates has historically been recognized as displaying a …

Study Design. A 3-year prospective, cohort study. Objectives. To compare the incidence and
risk factors of dysphagia after anterior cervical (AC), posterior cervical (PC), and posterior …

Gene targeting studies have shown that the transcription factor SCL is critically important for
embryonic hematopoiesis, but the early lethality of SCL null mice has precluded the genetic …

The LMO2 oncogene causes a subset of human T cell acute lymphoblastic leukemias (T-
ALL), including four cases that arose as adverse events in gene therapy trials. To investigate …

Many environmental issues facing society demand considerable public investment to
reverse. However, this investment will only arise if the general community is supportive, and …

Scl and Lyl1 encode two related basic-helix-loop-helix transcription factors implicated in T
cell acute lymphoblastic leukemia. Previous studies showed that Scl is essential for …