Vascular integrity in the healthy endothelium is maintained through the release of a variety
of paracrine factors such as NO (nitric oxide). Endothelial dysfunction, characterized by …

Background Germline pathogenic variants in SDHB/SDHC/SDHD are the most frequent
causes of inherited phaeochromocytomas/paragangliomas. Insufficient information …

Context: Recent evidence suggests that plasma-free metanephrines provide a highly
sensitive test in patients requiring exclusion of pheochromocytoma. The diagnostic efficacy …

The pathophysiological mechanism of increased fractures in young adults with type 1
diabetes mellitus (T1DM) is unclear. We conducted a case‐control study of trabecular bone …

Context Standard glucocorticoid therapy in congenital adrenal hyperplasia (CAH) regularly
fails to control androgen excess, causing glucocorticoid overexposure and poor health …

Catecholamines (epinephrine and norepinephrine) are synthesised and produced by the
adrenal medulla and postganglionic nerve fibres of the sympathetic nervous system. It is …

Context: Pheochromocytoma/paraganglioma occurs almost exclusively after paternal
transmission of succinate dehydrogenase D (SDHD) mutations. This parent-of-origin effect …

Objective Poorly controlled salt-wasting (SW) congenital adrenal hyperplasia (CAH) patients
often require high 9α-fluorocortisol doses as they show high levels of 17 …

Prior moderate exercise has been shown consistently to reduce postprandial triglyceride
(TG) concentrations in non-diabetic adults, but its effects in men with type 2 diabetes are not …

Insulin sensitivity in tissues such as a skeletal muscle and fat is closely correlated with
insulin action in the vasculature, but the mechanism underlying this is unclear. We …