User profiles for "author:C Spits"
Claudia SpitsVrije Universiteit Brussel Verified email at vub.ac.be Cited by 3961 |
The consequences of recurrent genetic and epigenetic variants in human pluripotent stem cells
It is well established that human pluripotent stem cells (hPSCs) can acquire genetic and
epigenetic changes during culture in vitro. Given the increasing use of hPSCs in research …
epigenetic changes during culture in vitro. Given the increasing use of hPSCs in research …
Recent developments in genetics and medically-assisted reproduction: from research to clinical applications
Two leading European professional societies, the European Society of Human Genetics and
the European Society for Human Reproduction and Embryology, have worked together …
the European Society for Human Reproduction and Embryology, have worked together …
Genetic and epigenetic instability in human pluripotent stem cells
BACKGROUND There is an increasing body of evidence that human pluripotent stem cells
(hPSCs) are prone to (epi) genetic instability during in vitro culture. This review aims at …
(hPSCs) are prone to (epi) genetic instability during in vitro culture. This review aims at …
Whole-genome multiple displacement amplification from single cells
C Spits, C Le Caignec, M De Rycke, L Van Haute… - Nature protocols, 2006 - nature.com
Multiple displacement amplification (MDA) is a recently described method of whole-genome
amplification (WGA) that has proven efficient in the amplification of small amounts of DNA …
amplification (WGA) that has proven efficient in the amplification of small amounts of DNA …
Recurrent chromosomal abnormalities in human embryonic stem cells
C Spits, I Mateizel, M Geens, A Mertzanidou… - Nature …, 2008 - nature.com
Cultured human embryonic stem (hES) cells have a known predisposition to aneuploidy of
chromosomes 12, 17 and X. We studied 17 hES cell lines by array-based comparative …
chromosomes 12, 17 and X. We studied 17 hES cell lines by array-based comparative …
Optimization and evaluation of single‐cell whole‐genome multiple displacement amplification
C Spits, C Le Caignec, M De Rycke… - Human …, 2006 - Wiley Online Library
The scarcity of genomic DNA can be a limiting factor in some fields of genetic research. One
of the methods developed to overcome this difficulty is whole genome amplification (WGA) …
of the methods developed to overcome this difficulty is whole genome amplification (WGA) …
Single-cell chromosomal imbalances detection by array CGH
Genomic imbalances are a major cause of constitutional and acquired disorders. Therefore,
aneuploidy screening has become the cornerstone of preimplantation, prenatal and …
aneuploidy screening has become the cornerstone of preimplantation, prenatal and …
Microarray analysis reveals abnormal chromosomal complements in over 70% of 14 normally developing human embryos
A Mertzanidou, L Wilton, J Cheng, C Spits… - Human …, 2013 - academic.oup.com
STUDY QUESTION What are the aneuploidy rates and incidence of mosaicism in good-
quality human preimplantation embryos. SUMMARY ANSWER High-level mosaicism and …
quality human preimplantation embryos. SUMMARY ANSWER High-level mosaicism and …
Gain of 20q11. 21 in human embryonic stem cells improves cell survival by increased expression of Bcl-xL
…, C Heirman, K Breckpot, C Spits - Molecular human …, 2014 - academic.oup.com
Abstract Gain of 20q11. 21 is a chromosomal abnormality that is recurrently found in human
pluripotent stem cells and cancers, strongly suggesting that this mutation confers a …
pluripotent stem cells and cancers, strongly suggesting that this mutation confers a …
[PDF][PDF] CpG methylation, a parent-of-origin effect for maternal-biased transmission of congenital myotonic dystrophy
CTG repeat expansions in DMPK cause myotonic dystrophy (DM1) with a continuum of
severity and ages of onset. Congenital DM1 (CDM1), the most severe form, presents distinct …
severity and ages of onset. Congenital DM1 (CDM1), the most severe form, presents distinct …