Success rates for genomic analyses of highly heterogeneous disorders can be greatly
improved if a large cohort of patient data is assembled to enhance collective capabilities for …

High-throughput screens have begun to reveal the protein interaction network that
underpins most cellular functions in the yeast Saccharomyces cerevisiae. How the …

Deleting a gene in an organism often has little phenotypic effect,,,,, owing to two
mechanisms of compensation,,,,,,. The first is the existence of duplicate genes: that is, the …

Many high-throughput experimental technologies have been developed to assess the
effects of large numbers of mutations (variation) on phenotypes. However, designing …

Protein–protein interactions are fundamental to many biological processes. Experimental
screens have identified tens of thousands of interactions, and structural biology has …

High similarity between yeast and human mitochondria allows functional genomic study of
Saccharomyces cerevisiae to be used to identify human genes involved in disease 1. So far …

Wolfram syndrome is an autosomal recessive disorder characterized by juvenile diabetes
mellitus, diabetes insipidus, optic atrophy and a number of neurological symptoms including …

High mutation rate in mammalian mitochondrial DNA generates a highly divergent pool of
alleles even within species that have dispersed and expanded in size recently. Phylogenetic …

X-linked congenital stationary night blindness (XLCSNB) is characterized by impaired
scotopic vision with associated ocular symptoms such as myopia, hyperopia, nystagmus and …

Coevolutionary sequence analysis has become a commonly used technique for de novo
prediction of the structure and function of proteins, RNA, and protein complexes. We present …