Recent advances in the development of 1, 8-naphthalimide based DNA targeting binders, anticancer and fluorescent cellular imaging agents

S Banerjee, EB Veale, CM Phelan… - Chemical Society …, 2013 - pubs.rsc.org
The development of functional 1, 8-naphthalimide derivatives as DNA targeting, anticancer
and cellular imaging agents is a fast growing area and has resulted in several such …

The OncoArray Consortium: a network for understanding the genetic architecture of common cancers

CI Amos, J Dennis, Z Wang, J Byun… - … , biomarkers & prevention, 2017 - AACR
Background: Common cancers develop through a multistep process often including
inherited susceptibility. Collaboration among multiple institutions, and funding from multiple …

Global ovarian cancer health disparities

G Chornokur, EK Amankwah, JM Schildkraut… - Gynecologic …, 2013 - Elsevier
OBJECTIVE: The objective of this article is to broadly review the scientific literature and
summarize the most up-to-date findings on ovarian cancer health disparities worldwide and …

Evidence for the complete inactivation of the NF2 gene in the majority of sporadic meningiomas

MH Ruttledge, J Sarrazin, S Rangaratnam… - Nature …, 1994 - nature.com
Meningiomas are common central nervous system tumours which present usually in the 4th
and 5th decades of life. Loss of constitutional heterozygosity on chromosome 22 in 60% of …

GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer

PDP Pharoah, YY Tsai, SJ Ramus, CM Phelan… - Nature …, 2013 - nature.com
Genome-wide association studies (GWAS) have identified four susceptibility loci for
epithelial ovarian cancer (EOC), with another two suggestive loci reaching near genome …

Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer

CM Phelan, KB Kuchenbaecker, JP Tyrer, SP Kar… - Nature …, 2017 - nature.com
To identify common alleles associated with different histotypes of epithelial ovarian cancer
(EOC), we pooled data from multiple genome-wide genotyping projects totaling 25,509 EOC …

BRCA2 mutations in primary breast and ovarian cancers

JM Lancaster, R Wooster, J Mangion, CM Phelan… - Nature …, 1996 - nature.com
The second hereditary breast cancer gene, BRCA2, was recently isolated1. Germline
mutations of this gene predispose carriers to breast cancer, and, to a lesser extent, ovarian …

[HTML][HTML] Genome-Wide Association Study in BRCA1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk

FJ Couch, X Wang, L McGuffog, A Lee, C Olswold… - PLoS …, 2013 - journals.plos.org
BRCA1-associated breast and ovarian cancer risks can be modified by common genetic
variants. To identify further cancer risk-modifying loci, we performed a multi-stage GWAS of …

Identification of six new susceptibility loci for invasive epithelial ovarian cancer

KB Kuchenbaecker, SJ Ramus, J Tyrer, A Lee… - Nature …, 2015 - nature.com
Genome-wide association studies (GWAS) have identified 12 epithelial ovarian cancer
(EOC) susceptibility alleles. The pattern of association at these loci is consistent in BRCA1 …

[HTML][HTML] Global patterns of prostate cancer incidence, aggressiveness, and mortality in men of african descent

TR Rebbeck, SS Devesa, BL Chang, CH Bunker… - Prostate cancer, 2013 - hindawi.com
Prostate cancer (CaP) is the leading cancer among men of African descent in the USA,
Caribbean, and Sub-Saharan Africa (SSA). The estimated number of CaP deaths in SSA …