Mammalian sex determination is governed by the presence of the sex determining region Y
gene (SRY) on the Y chromosome 1. Familial cases of SRY-negative XX sex reversal are …

MATERIALS AND METHODS Comparative sequence analysis To obtain the full length
mouse sequence, we directly sequenced by primer walking8 the BAC 13L19 (RP23 Mouse …

In this review, we describe recent results concerning the genetics of sex determination in
mammals. Particularly, we developed the study of the FOXL2 gene and its implication in …

Previous studies have equated FOXL2 as a crucial actor in the ovarian differentiation
process in different vertebrate species. Its transcriptional extinction in the polled intersex …

The origin of sex reversal in XX goats homozygous for the polled intersex syndrome (PIS)
mutation was unclear because of the complexity of the mutation that affects the transcription …

Mutations in the forkhead transcription factor gene FOXL2 are involved in ovarian failure,
which occurs in human BPES syndrome. This syndrome presents a sexually dimorphic …

Objective The goal of this study was to determine whether mutations of meiotic genes, such
as disrupted meiotic cDNA (DMC1), MutS homolog (MSH4), MSH5, and S. cerevisiae …

In humans, the choice between male or female development is genetically determined. Sex
determination take place when the bipotential embryonic gonad becomes either testis or …

Background Ubiquitous environmental chemicals, including endocrine-disrupting chemicals
(EDCs), are associated with declining human reproductive health, as well as an increasing …

In humans, testis development depends on a regulated genetic hierarchy initiated by the Y-
linked SRY gene. Failure of testicular determination results in the condition termed 46, XY …