A major goal of proteomics is the complete description of the protein interaction network
underlying cell physiology. A large number of small scale and, more recently, large-scale …

Abstract The Myogenic Regulatory Factors (MRFs) Myf5, MyoD, myogenin and MRF4 are
members of the basic helix-loop-helix family of transcription factors that control the …

Muscle stem cells, or satellite cells, are required for skeletal muscle maintenance, growth,
and repair. Following satellite cell activation, several factors drive asymmetric cell division to …

Background Analyses of biomolecules for biodiversity, phylogeny or structure/function
studies often use graphical tree representations. Many powerful tree editors are now …

The Drosophila (fruit fly) model system has been instrumental in our current understanding
of human biology, development, and diseases. Here, we used a high-throughput yeast two …

Natural chromosomal ends are stabilized by proteins that bind duplex telomeric DNA
repeats. In human cells, the T TAGGG R epeat F actor 1 (TRF1) was identified by two …

Dystrophin is expressed in differentiated myofibers, in which it is required for sarcolemmal
integrity, and loss-of-function mutations in the gene that encodes it result in Duchenne …

The authors describe a technic for aspiration biopsy of renal tissue in man. Biopsies from
two normal individuals and from five patients with various renal disorders are reported in …

A fraction of cancer cells maintain telomeres through the telomerase-independent,'
Alternative Lengthening of Telomeres'(ALT) pathway. ALT relies on homologous …

We have developed methods and tools based on the Gene Ontology (GO) resource allowing
the identification of statistically over-or under-represented terms in a gene dataset; the …