Purpose: The purpose of this statement is to review the literature regarding mitochondrial
disease and to provide recommendations for optimal diagnosis and treatment. This …

Mitochondrial disease confirmation and establishment of a specific molecular diagnosis
requires extensive clinical and laboratory evaluation. Dual genome origins of mitochondrial …

Opinion statement The treatment of mitochondrial disease varies considerably. Most experts
use a combination of vitamins, optimize patients' nutrition and general health, and prevent …

Purpose: Medulloblastoma is the most common malignant brain tumor of childhood. After
treatment with surgery and radiation therapy, approximately 60% of children with …

✓ It has previously been reported in a single-institution trial that progression-free survival of
children with medulloblastoma treated with radiotherapy and 1-(2-chloroethyl)-3-cyclohexyl …

Notorious variability in the presentation of mitochondrial disease in the infant and young
child complicates its clinical diagnosis. Mitochondrial disease is not a single entity but …

Intracranial germ cell tumors are a heterogeneous group of lesions which occur in children
and adults. Within the classification of intracranial germ cell tumors, there are a variety of …

Mutations in the POLG gene have emerged as one of the most common causes of inherited
mitochondrial disease in children and adults. They are responsible for a heterogeneous …

Background Previous reports indicate an association between autism spectrum disorders
(ASD) and disorders of mitochondrial oxidative phosphorylation. One study suggested that …

The purpose of this statement is to provide consensus-based recommendations for optimal
management and care for patients with primary mitochondrial disease. This statement is …