User profiles for "author:Brian H Shirts"
Brian H ShirtsAssociate Professor of Laboratory Medicine, University of Washington Verified email at uw.edu Cited by 6546 |
Do we now know what inappropriate laboratory utilization is? An expanded systematic review of laboratory clinical audits
Objectives: Many nonpathologists and some pathologists consider utilization review
essential to laboratory quality improvement, but (1) confusion surrounding the definition of …
essential to laboratory quality improvement, but (1) confusion surrounding the definition of …
Prevalence and spectrum of germline cancer susceptibility gene mutations among patients with early-onset colorectal cancer
R Pearlman, WL Frankel, B Swanson, W Zhao… - JAMA …, 2017 - jamanetwork.com
Importance Hereditary cancer syndromes infer high cancer risks and require intensive
cancer surveillance, yet the prevalence and spectrum of these conditions among unselected …
cancer surveillance, yet the prevalence and spectrum of these conditions among unselected …
[PDF][PDF] Actionable, pathogenic incidental findings in 1,000 participants' exomes
MO Dorschner, LM Amendola, EH Turner… - The American Journal of …, 2013 - cell.com
The incorporation of genomics into medicine is stimulating interest on the return of incidental
findings (IFs) from exome and genome sequencing. However, no large-scale study has yet …
findings (IFs) from exome and genome sequencing. However, no large-scale study has yet …
Actionable exomic incidental findings in 6503 participants: challenges of variant classification
LM Amendola, MO Dorschner, PD Robertson… - Genome …, 2015 - genome.cshlp.org
Recommendations for laboratories to report incidental findings from genomic tests have
stimulated interest in such results. In order to investigate the criteria and processes for …
stimulated interest in such results. In order to investigate the criteria and processes for …
Sequence specificity of aminoglycoside‐induced stop codon readthrough: Potential implications for treatment of Duchenne muscular dystrophy
MT Howard, BH Shirts, LM Petros… - Annals of Neurology …, 2000 - Wiley Online Library
As a result of their ability to induce translational readthrough of stop codons, the
aminoglycoside antibiotics are currently being tested for efficacy in the treatment of …
aminoglycoside antibiotics are currently being tested for efficacy in the treatment of …
Assessment of tumor sequencing as a replacement for Lynch syndrome screening and current molecular tests for patients with colorectal cancer
H Hampel, R Pearlman, M Beightol, W Zhao… - JAMA …, 2018 - jamanetwork.com
Importance Universal tumor screening for Lynch syndrome (LS) in colorectal cancer (CRC)
is recommended and involves up to 6 sequential tests. Somatic gene testing is performed on …
is recommended and involves up to 6 sequential tests. Somatic gene testing is performed on …
[HTML][HTML] Inherited TP53 variants and risk of prostate cancer
Background Inherited germline TP53 pathogenic and likely pathogenic variants (gTP53)
cause autosomal dominant multicancer predisposition including Li-Fraumeni syndrome …
cause autosomal dominant multicancer predisposition including Li-Fraumeni syndrome …
[HTML][HTML] Next-generation sequencing panels for the diagnosis of colorectal cancer and polyposis syndromes: a cost-effectiveness analysis
CJ Gallego, BH Shirts, CS Bennette… - Journal of Clinical …, 2015 - ncbi.nlm.nih.gov
Next-Generation Sequencing Panels for the Diagnosis of Colorectal Cancer and Polyposis
Syndromes: A Cost-Effectiveness Analysis - PMC Back to Top Skip to main content NIH NLM …
Syndromes: A Cost-Effectiveness Analysis - PMC Back to Top Skip to main content NIH NLM …
Comparison of CDH1 penetrance estimates in clinically ascertained families vs families ascertained for multiple gastric cancers
ME Roberts, JMO Ranola, ML Marshall… - JAMA …, 2019 - jamanetwork.com
Importance CDH1pathogenic variants have been estimated to confer a 40% to 70% and
56% to 83% lifetime risk for gastric cancer in men and women, respectively. These are likely …
56% to 83% lifetime risk for gastric cancer in men and women, respectively. These are likely …
Antibodies to cytomegalovirus and Herpes Simplex Virus 1 associated with cognitive function in schizophrenia
BACKGROUND:: Cognitive impairment in the form of decreased working memory and
executive functions has been recognized as a key deficit in schizophrenia. Neurotropic …
executive functions has been recognized as a key deficit in schizophrenia. Neurotropic …