Objectives: Many nonpathologists and some pathologists consider utilization review
essential to laboratory quality improvement, but (1) confusion surrounding the definition of …

Importance Hereditary cancer syndromes infer high cancer risks and require intensive
cancer surveillance, yet the prevalence and spectrum of these conditions among unselected …

The incorporation of genomics into medicine is stimulating interest on the return of incidental
findings (IFs) from exome and genome sequencing. However, no large-scale study has yet …

Recommendations for laboratories to report incidental findings from genomic tests have
stimulated interest in such results. In order to investigate the criteria and processes for …

As a result of their ability to induce translational readthrough of stop codons, the
aminoglycoside antibiotics are currently being tested for efficacy in the treatment of …

Importance Universal tumor screening for Lynch syndrome (LS) in colorectal cancer (CRC)
is recommended and involves up to 6 sequential tests. Somatic gene testing is performed on …

Background Inherited germline TP53 pathogenic and likely pathogenic variants (gTP53)
cause autosomal dominant multicancer predisposition including Li-Fraumeni syndrome …

Next-Generation Sequencing Panels for the Diagnosis of Colorectal Cancer and Polyposis
Syndromes: A Cost-Effectiveness Analysis - PMC Back to Top Skip to main content NIH NLM …

Importance CDH1pathogenic variants have been estimated to confer a 40% to 70% and
56% to 83% lifetime risk for gastric cancer in men and women, respectively. These are likely …

BACKGROUND:: Cognitive impairment in the form of decreased working memory and
executive functions has been recognized as a key deficit in schizophrenia. Neurotropic …