Evidence is growing for the long-term effects of environmental factors during early-life on
later disease susceptibility. It is believed that epigenetic mechanisms (changes in gene …

The world's poorest children are likely to be malnourished when receiving their childhood
vaccines. It is uncertain whether this affects vaccine efficacy and whether the …

In experimental animals, maternal diet during the periconceptional period influences the
establishment of DNA methylation at metastable epialleles in the offspring, with permanent …

Seasonal variations are rarely considered a contributing component to human tissue
function or health, although many diseases and physiological process display annual …

In this trans-ethnic multi-omic study, we reinterpret the genetic architecture of blood pressure
to identify genes, tissues, phenomes and medication contexts of blood pressure …

Birth weight within the normal range is associated with a variety of adult-onset diseases, but
the mechanisms behind these associations are poorly understood. Previous genome-wide …

Africa is the ultimate source of modern humans and as such harbors more genetic variation
than any other continent. For this reason, studies of the patterns of genetic variation in …

This article challenges Speakman's hypothesis that the modern genetic predisposition to
obesity has arisen through random genetic drift in the two million years following predation …

Background Interindividual epigenetic variation that occurs systemically must be established
prior to gastrulation in the very early embryo and, because it is systemic, can be assessed in …

Background: Animal models show that periconceptional supplementation with folic acid,
vitamin B-12, choline, and betaine can induce differences in offspring phenotype mediated …