Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
By combining genome-wide association data from 8,130 individuals with type 2 diabetes
(T2D) and 38,987 controls of European descent and following up previously unidentified …
(T2D) and 38,987 controls of European descent and following up previously unidentified …
Latent autoimmune diabetes of adults (LADA) is likely to represent a mixed population of autoimmune (type 1) and nonautoimmune (type 2) diabetes
Latent autoimmune diabetes of adults (LADA) is typically defined as a new diabetes
diagnosis after 35 years of age, presenting with clinical features of type 2 diabetes, in whom …
diagnosis after 35 years of age, presenting with clinical features of type 2 diabetes, in whom …
Can clinical features be used to differentiate type 1 from type 2 diabetes? A systematic review of the literature
Objective Clinicians predominantly use clinical features to differentiate type 1 from type 2
diabetes yet there are no evidence-based clinical criteria to aid classification of patients …
diabetes yet there are no evidence-based clinical criteria to aid classification of patients …
Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A
S Nejentsev, JMM Howson, NM Walker, J Szeszko… - Nature, 2007 - nature.com
The major histocompatibility complex (MHC) on chromosome 6 is associated with
susceptibility to more common diseases than any other region of the human genome …
susceptibility to more common diseases than any other region of the human genome …
Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors
Birth weight variation is influenced by fetal and maternal genetic and non-genetic factors,
and has been reproducibly associated with future cardio-metabolic health outcomes. In …
and has been reproducibly associated with future cardio-metabolic health outcomes. In …
[HTML][HTML] Frequency and phenotype of type 1 diabetes in the first six decades of life: a cross-sectional, genetically stratified survival analysis from UK Biobank
Background Type 1 diabetes is typically considered a disease of children and young adults.
Genetic susceptibility to young-onset type 1 diabetes is well defined and does not …
Genetic susceptibility to young-onset type 1 diabetes is well defined and does not …
[HTML][HTML] Disease progression and treatment response in data-driven subgroups of type 2 diabetes compared with models based on simple clinical features: an …
Background Research using data-driven cluster analysis has proposed five subgroups of
diabetes with differences in diabetes progression and risk of complications. We aimed to …
diabetes with differences in diabetes progression and risk of complications. We aimed to …
New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism
Birth weight within the normal range is associated with a variety of adult-onset diseases, but
the mechanisms behind these associations are poorly understood. Previous genome-wide …
the mechanisms behind these associations are poorly understood. Previous genome-wide …
Prevalence of vascular complications among patients with glucokinase mutations and prolonged, mild hyperglycemia
AM Steele, BM Shields, KJ Wensley, K Colclough… - Jama, 2014 - jamanetwork.com
Importance Glycemic targets in diabetes have been developed to minimize complication
risk. Patients with heterozygous, inactivating glucokinase (GCK) mutations have mild fasting …
risk. Patients with heterozygous, inactivating glucokinase (GCK) mutations have mild fasting …
Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight
To identify genetic variants associated with birth weight, we meta-analyzed six genome-wide
association (GWA) studies (n= 10,623 Europeans from pregnancy/birth cohorts) and …
association (GWA) studies (n= 10,623 Europeans from pregnancy/birth cohorts) and …