Talin has emerged as the key cytoplasmic protein that mediates integrin adhesion to the
extracellular matrix. In this Review, we draw on experiments performed in mammalian cells …

Talin, a force-bearing cytoplasmic adapter essential for integrin-mediated cell adhesion,
links the actin cytoskeleton to integrin-based cell–extracellular matrix adhesions at the …

Mediator is a large, modular protein complex remotely conserved from yeast to man that
conveys regulatory signals from DNA-binding transcription factors to RNA polymerase II. In …

We highlight recent progress in understanding cadherin and integrin function in the model
organism Drosophila. New functions for these adhesion receptors continue to be discovered …

Cell-matrix adhesion is essential for building animals, promoting tissue cohesion, and
enabling cells to migrate and resist mechanical force. Talin is an intracellular protein that is …

Vinculin is a highly conserved protein involved in cell adhesion and mechanotransduction,
and both gain and loss of its activity causes defective cell behaviour. Here, we examine how …

The endocycle constitutes an effective strategy for cell growth during development. In
contrast to the mitotic cycle, it consists of multiple S-phases with no intervening mitosis and …

Background Heterozygous germline loss-of-function mutations in the aryl hydrocarbon
receptor-interacting protein gene (AIP) predispose to childhood-onset pituitary tumours. The …

In various organisms, thioredoxins are known to be involved in the reduction of protein
disulfide bonds and in protecting the cell from oxidative stress. Genes encoding thioredoxins …

Vinculin is a mechanosensitive adapter protein that links the actin network to cell-
extracellular matrix adhesions and cell-cell adhesions. It is perhaps the best characterized …