Aspirin and other nonsteroidal anti‐inflammatory drugs (NSAIDs) are among the most
common causes of adverse drug reactions. Majority of them are of the hypersensitivity type …

The present approach to the diagnosis, management and follow‐up of anaphylaxis during
anaesthesia varies in the Scandinavian countries. The main purpose of these Scandinavian …

The allergen bronchoprovocation test is a long-standing exacerbation model of allergic
asthma that can induce several clinical and pathophysiologic features of asthma in …

U-BIOPRED is a European Union consortium of 20 academic institutions, 11 pharmaceutical
companies and six patient organisations with the objective of improving the understanding …

Leukotriene antagonists block the proinflammatory actions of leukotrienes (LT) and have
been introduced as new treatments for asthma. Conventional therapy with …

Background Asthma is a heterogeneous disease in which there is a differential response to
asthma treatments. This heterogeneity needs to be evaluated so that a personalized …

In vivo production of thromboxane (TX) A2 and the cysteinyl-containing leukotrienes (LT) C4,
D4, and E4 in correlation to airway responses was studied. Bronchial provocation with …

We defined the contribution of histamine and leukotrienes to allergen-induced airway
obstruction in asthmatics; 12 subjects with allergic asthma underwent identical allergen …

Background Exacerbations represent a major source of morbidity and mortality in asthma
and are a prominent feature of poorly controlled, difficult‐to‐treat disease. Objective The …

The causes of severe childhood asthma are poorly understood. Our aim was to define global
patterns of gene expression in children with severe therapy-resistant and controlled asthma …