Childhood adrenocortical tumors (ACT) are very aggressive endocrine neoplasms whose
incidence is quite low. Little is known about their pathogenesis, clinical presentation, and …

Childhood adrenocortical tumors (ACT) are rare. In the USA, only about 25 new cases occur
each year. In Southern Brazil, however, approximately 10 times that many cases are …

Adrenocortical tumors (ACT) in children are very rare and are most frequently diagnosed in
the context of the Li-Fraumeni syndrome, a multiple cancer syndrome linked to germline …

MicroRNAs (miRNAs) act at the posttranscriptional level to control gene expression in
virtually every biological process, including oncogenesis. Here, we report the identification …

Impact of Neonatal Screening and Surveillance for the TP53 R337H Mutation on Early
Detection of Childhood Adrenocortical Tumors - PMC Back to Top Skip to main content NIH …

Abstract Steroidogenic factor-1 (SF-1/Ad4BP; NR5A1), a nuclear receptor transcription
factor, has a pivotal role in adrenal and gonadal development in humans and mice. A …

Paediatric adrenocortical carcinoma is a rare malignancy with poor prognosis. Here we
analyse 37 adrenocortical tumours (ACTs) by whole-genome, whole-exome and/or …

Background: An inherited germline P53 mutation has been identified in cases of childhood
adrenocortical carcinoma (ACT), a neoplasm with a high incidence in southern Brazil. The …

Southern Brazil has one of the highest incidences of childhood adrenocortical tumors
(ACTs), occurring 10–15 times more frequently than worldwide estimates. The reasons for …

Although several genes have been investigated in adrenal tumorigenesis, the genetic
background of adrenocortical tumors (ACT) remains poorly characterized. In southern Brazil …