MicroRNAs (miRNAs) are a novel class of small endogenous non-coding RNAs that
regulate gene expression post-transcriptionally by binding to their cognate target mRNAs …

The neurotransmitter glutamate facilitates neuronal signalling at excitatory synapses.
Glutamate is released from the presynaptic membrane into the synaptic cleft. Across the …

Although the role of APP and PSEN genes in genetic Alzheimer's disease (AD) cases is well
established, fairly little is known about the molecular mechanisms affecting Aβ generation in …

Abstract MicroRNA-122 (miR-122) is an abundant liver-specific miRNA, implicated in fatty
acid and cholesterol metabolism as well as hepatitis C viral replication. Here, we report that …

MicroRNAs (miRNA) are a class of small noncoding RNAs with important posttranscriptional
regulatory functions. Recent data suggest that miRNAs are aberrantly expressed in many …

MicroRNAs (miRNAs) are a new class of short noncoding regulatory RNAs (18–25
nucleotides) that are involved in diverse developmental and pathologic processes. Altered …

This article focuses on the role of the interchromatin compartment (IC) in shaping nuclear
landscapes. The IC is connected with nuclear pore complexes (NPCs) and harbors splicing …

microRNAs are∼ 22 nucleotide endogenous noncoding RNAs that post-transcriptionally
repress expression of protein-coding genes by base-pairing with the 3′-untranslated …

Abstract microRNAs (miRNA) are involved in cancer development and progression, acting
as tumor suppressors or oncogenes. Here, we profiled the expression of 290 unique human …

Abstract Type III RNase Dicer is responsible for the maturation and function of microRNA
(miRNA) molecules in the cell. It is now well-documented that Dicer and the fine-tuning of …