Macrophages from the peripheral circulation and those derived from resident microglia are
among the main effector cells of the inflammatory response that follows spinal cord trauma …

Significance: Iron accumulation occurs in the central nervous system (CNS) in a variety of
neurological conditions as diverse as spinal cord injury, stroke, multiple sclerosis …

Myeloid cells are important effector cells in the injured spinal cord tissue. Microglia and
monocyte-derived macrophages serve important functions in the injured spinal cord, and …

Macrophages and microglia can be polarized along a continuum toward a detrimental (M1)
or a beneficial (M2) state in the injured CNS. Although phagocytosis of myelin in vitro …

T cells are considered to play a pivotal role in orchestrating the self‐reactive immune
responses in multiple sclerosis (MS). Programmed death 1 (PD‐1) is a member of the …

A rapid proinflammatory response after peripheral nerve injury is required for clearance of
tissue debris (Wallerian degeneration) and effective regeneration. Unlike the CNS, this …

Overexpression of the major myelin protein of the CNS, proteolipid protein (PLP), leads to
late-onset degeneration of myelin and pathological changes in axons. Based on the …

Background Secondary damage after spinal cord injury (SCI) is characterized by a cascade
of events including hemorrhage, apoptosis, oxidative stress, and inflammation which …

How iron is delivered to the CNS for myelination is not well understood. We assessed
whether astrocytes can provide iron to cells in the CNS for remyelination. To study this we …

Damaged central nervous system (CNS) neurons have a poor ability to spontaneously
regenerate, causing persistent functional deficits after injury. Therapies that stimulate axon …