[HTML][HTML] Sirolimus and kidney growth in autosomal dominant polycystic kidney disease
AL Serra, D Poster, AD Kistler, F Krauer… - … England Journal of …, 2010 - Mass Medical Soc
Background In autosomal dominant polycystic kidney disease (ADPKD), aberrant activation
of the mammalian target of rapamycin (mTOR) pathway is associated with progressive …
of the mammalian target of rapamycin (mTOR) pathway is associated with progressive …
[HTML][HTML] Angiotensin II contributes to podocyte injury by increasing TRPC6 expression via an NFAT-mediated positive feedback signaling pathway
T Nijenhuis, AJ Sloan, JGJ Hoenderop… - The American journal of …, 2011 - Elsevier
The transient receptor potential channel C6 (TRPC6) is a slit diaphragm–associated protein
in podocytes involved in regulating glomerular filter function. Gain-of-function mutations in …
in podocytes involved in regulating glomerular filter function. Gain-of-function mutations in …
[HTML][HTML] Altered glycosylation of IgG4 promotes lectin complement pathway activation in anti-PLA2R1–associated membranous nephropathy
G Haddad, JM Lorenzen, H Ma… - The Journal of …, 2021 - Am Soc Clin Investig
Primary membranous nephropathy (pMN) is a leading cause of nephrotic syndrome in
adults. In most cases, this autoimmune kidney disease is associated with autoantibodies …
adults. In most cases, this autoimmune kidney disease is associated with autoantibodies …
[HTML][HTML] Toward the development of podocyte-specific drugs
Most kidney diseases that ultimately lead to end-stage renal failure originate within the
glomerulus and are associated with proteinuria. Treatment options are unspecific and offer …
glomerulus and are associated with proteinuria. Treatment options are unspecific and offer …
[HTML][HTML] CD2AP in mouse and human podocytes controls a proteolytic program that regulates cytoskeletal structure and cellular survival
S Yaddanapudi, MM Altintas, AD Kistler… - The Journal of …, 2011 - Am Soc Clin Investig
Kidney podocytes are highly differentiated epithelial cells that form interdigitating foot
processes with bridging slit diaphragms (SDs) that regulate renal ultrafiltration. Podocyte …
processes with bridging slit diaphragms (SDs) that regulate renal ultrafiltration. Podocyte …
Specific proteolytic cleavage of agrin regulates maturation of the neuromuscular junction
MF Bolliger, A Zurlinden, D Lüscher… - Journal of cell …, 2010 - journals.biologists.com
During the initial stage of neuromuscular junction (NMJ) formation, nerve-derived agrin
cooperates with muscle-autonomous mechanisms in the organization and stabilization of a …
cooperates with muscle-autonomous mechanisms in the organization and stabilization of a …
[HTML][HTML] Increases in kidney volume in autosomal dominant polycystic kidney disease can be detected within 6 months
AD Kistler, D Poster, F Krauer, D Weishaupt, S Raina… - Kidney international, 2009 - Elsevier
Kidney volume growth is considered the best surrogate marker predicting the decline of
renal function in autosomal dominant polycystic kidney disease. To assess the therapeutic …
renal function in autosomal dominant polycystic kidney disease. To assess the therapeutic …
The mTOR inhibitor rapamycin significantly improves facial angiofibroma lesions in a patient with tuberous sclerosis
GFL Hofbauer, A Marcollo‐Pini… - British Journal of …, 2008 - academic.oup.com
Tuberous sclerosis complex (TSC) is an autosomal dominant disorder with an incidence of
approximately one in 6000. It arises from a genetic abnormality involving either the TSC1 …
approximately one in 6000. It arises from a genetic abnormality involving either the TSC1 …
Complement activation and effector pathways in membranous nephropathy
AD Kistler, DJ Salant - Kidney International, 2023 - Elsevier
Complement activation has long been recognized as a central feature of membranous
nephropathy. Evidence for its role has been derived from the detection of complement …
nephropathy. Evidence for its role has been derived from the detection of complement …
[HTML][HTML] Patients with autosomal dominant polycystic kidney disease have elevated fibroblast growth factor 23 levels and a renal leak of phosphate
I Pavik, P Jaeger, AD Kistler, D Poster, F Krauer… - Kidney international, 2011 - Elsevier
Fibroblast growth factor 23 (FGF23) and parathyroid hormone blood levels rise following
progressive loss of renal function. Here we measured parameters of phosphate metabolism …
progressive loss of renal function. Here we measured parameters of phosphate metabolism …