At the beginning of the 21st Century, obesity has become the leading metabolic disease in
the World. So much so, that the World Health Organisation refers to obesity as the global …

Abstract This Consensus Statement summarizes recommendations for clinical diagnosis,
investigation and management of patients with Silver–Russell syndrome (SRS), an …

The etiology of central precocious puberty (CPP) is multiple and heterogeneous, including
congenital and acquired causes that can be associated with structural or functional brain …

Hashimoto's encephalopathy is a severe and rather infrequent clinical condition initially
described in patients suffering from chronic lymphocytic thyroiditis. Its origin is still …

Background Delta-like homolog 1 (DLK1), also called preadipocyte factor 1, prevents
adipocyte differentiation and has been considered a molecular gatekeeper of adipogenesis …

Background The resting metabolic rate (RMR) decrease, observed after an obesity reduction
therapy is a determinant of a short-time weight regain. Thus, the objective of this study was …

OBJECTIVE—To evaluate the intravitreous concentration of vascular cell adhesion molecule
(VCAM)-1 in diabetic patients with proliferative diabetic retinopathy (PDR) and the …

Context Loss-of-function mutations of makorin RING finger protein 3 (MKRN3) are the most
common monogenic cause of familial central precocious puberty (CPP). Objective To …

Background Identification of genetic causes of central precocious puberty have revealed
epigenetic mechanisms as regulators of human pubertal timing. MECP2, an X-linked gene …

Pubertal timing in humans is determined by complex interactions including hormonal,
metabolic, environmental, ethnic, and genetic factors. Central precocious puberty (CPP) is …