Mitochondria are highly dynamic organelles which play a central role in cellular
homeostasis. Mitochondrial dysfunction leads to life-threatening disorders and accelerates …

Frataxin is a nuclear-encoded mitochondrial protein involved in the biogenesis of Fe-S-
cluster-containing proteins and consequently in the functionality of the mitochondrial …

Ageing constitutes the most important risk factor for all major chronic ailments, including
malignant, cardiovascular and neurodegenerative diseases. However, behavioural and …

Mitochondrial pathologies underlie a number of life‐shortening diseases in humans. In the
nematode Caenorhabditis elegans, severely reduced expression of mitochondrial proteins …

Aging is characterized by the deterioration of different cellular and organismal structures and
functions. A typical hallmark of the aging process is the accumulation of dysfunctional …

Severe mitochondria deficiency leads to a number of devastating degenerative disorders,
yet, mild mitochondrial dysfunction in different species, including the nematode …

Background and aim We identified a balanced de novo translocation involving
chromosomes Xq25 and 8q24 in an eight year-old girl with a non-progressive form of …

Progressive neuronal deterioration accompanied by sensory functions decline is typically
observed during aging. On the other hand, structural or functional alterations of specific …

Excessive iron accumulation or deficiency leads to a variety of pathologies in humans and
developmental arrest in the nematode Caenorhabditis elegans. Instead, sub-lethal iron …

Autophagy and the circadian clock counteract tissue degeneration and support longevity in
many organisms. Accumulating evidence indicates that aging compromises both the …