[HTML][HTML] Cancer risks associated with germline PALB2 pathogenic variants: an international study of 524 families

X Yang, G Leslie, A Doroszuk, S Schneider… - Journal of clinical …, 2020 - ncbi.nlm.nih.gov
PURPOSE To estimate age-specific relative and absolute cancer risks of breast cancer and
to estimate risks of ovarian, pancreatic, male breast, prostate, and colorectal cancers …

Genomic features and classification of homologous recombination deficient pancreatic ductal adenocarcinoma

T Golan, GM O'Kane, RE Denroche… - Gastroenterology, 2021 - Elsevier
Background and Aims Homologous recombination deficiency (HRD) in pancreatic ductal
adenocarcinoma (PDAC), remains poorly defined beyond germline (g) alterations in …

Resectable pancreatic adenocarcinoma: role of CT quantitative imaging biomarkers for predicting pathology and patient outcomes

C Cassinotto, J Chong, G Zogopoulos… - European journal of …, 2017 - Elsevier
Backgrounds Patients with a pancreatic cancer amenable to surgery still have a poor
prognosis and high risk of post-operative recurrence. We aimed to assess the value of …

[HTML][HTML] Reg proteins promote acinar-to-ductal metaplasia and act as novel diagnostic and prognostic markers in pancreatic ductal adenocarcinoma

Q Li, H Wang, G Zogopoulos, Q Shao, K Dong, F Lv… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignant tumor. Acinar-
to-ductal metaplasia (ADM) and pancreatic intraepithelial neoplasia (PanIN) are both …

A Preclinical Trial and Molecularly Annotated Patient Cohort Identify Predictive Biomarkers in Homologous Recombination–deficient Pancreatic Cancer

Y Wang, JYP Park, A Pacis, RE Denroche… - Clinical Cancer …, 2020 - AACR
Purpose: Pancreatic ductal adenocarcinoma (PDAC) arising in patients with a germline
BRCA1 or BRCA2 (g BRCA) mutation may be sensitive to platinum and PARP inhibitors …

Oncology clinic-based germline genetic testing for exocrine pancreatic cancer enables timely return of results and unveils low uptake of cascade testing

Y Wang, B Golesworthy, A Cuggia… - Journal of medical …, 2022 - jmg.bmj.com
Background Traditional medical genetics models are unable to meet the growing demand
for germline genetic testing (GT) in patients with exocrine pancreatic cancer (PC). This study …

Reflex Testing for Germline BRCA1, BRCA2, PALB2, and ATM Mutations in Pancreatic Cancer: Mutation Prevalence and Clinical Outcomes From Two Canadian …

AL Smith, C Wong, A Cuggia, A Borgida… - JCO precision …, 2018 - ascopubs.org
Purpose We investigated the translational value of reflex testing for germline mutations in
four homology-directed DNA repair predisposition genes (BRCA1, BRCA2, PALB2, and …

Pancreatic cancer progression in a patient with lynch syndrome receiving immunotherapy: A cautionary tale

Y Wang, A Cuggia, A Pacis, JC Boileau… - Journal of the National …, 2021 - jnccn.org
Pancreatic ductal adenocarcinomas (PDACs) with DNA mismatch repair deficiency (MMRd)
respond preferentially to immune checkpoint inhibitors (ICIs). However, a subset of MMRd …

[HTML][HTML] Intra-tumoral CD8+ T-Cell infiltration and PD-L1 positivity in homologous recombination deficient pancreatic ductal adenocarcinoma

B Golesworthy, Y Wang, A Tanti, A Pacis… - Frontiers in …, 2022 - frontiersin.org
The immune contexture of pancreatic ductal adenocarcinoma (PDAC) is generally
immunosuppressive. A role for immune checkpoint inhibitors (ICIs) in PDAC has only been …

Pancreatic adenocarcinoma: A simple CT score for predicting margin-positive resection in patients with resectable disease

C Cassinotto, A Dohan, G Zogopoulos, L Chiche… - European journal of …, 2017 - Elsevier
Background Negative-margin status is a prognostic indicator for long-term survival following
curative intent resection for pancreatic adenocarcinoma. Patients at increased risk for …