Aberrant interactions of transcriptional repressor proteins with the Huntington's disease gene product, huntingtin

…, J Duce, PS Harper, A Lesley Jones - Human molecular …, 1999 - academic.oup.com
We detected an interaction of the N-terminus of huntingtin (htt171) with the C-terminal region
of the nuclear receptor co-repressor (N-CoR) using the yeast two-hybrid system. This …

Age of onset in Huntington disease: sex specific influence of apolipoprotein E genotype and normal CAG repeat length

P Kehoe, M Krawczak, PS Harper, MJ Owen… - Journal of medical …, 1999 - jmg.bmj.com
Age of onset (AO) of Huntington disease (HD) is known to be correlated with the length of an
expanded CAG repeat in the HD gene. Apolipoprotein E (APOE) genotype, in turn, is known …

Huntingtin interacts with cystathionine β-synthase

JM Boutell, JD Wood, PS Harper… - Human molecular …, 1998 - academic.oup.com
We have screened a rat brain library to identify proteins which interact with the 5′-end of
huntingtin (amino acids 1–171), including the polyglutamine tract, in the yeast two-hybrid …

Partial characterisation of murine huntingtin and apparent variations in the subcellular localisation of huntingtin in human, mouse and rat brain

JD Wood, JC MacMillan, PS Harper… - Human molecular …, 1996 - academic.oup.com
Huntington's disease (HD) is an inherited neurodegenerative disorder caused by the
expansion of a CAG repeat in a gene coding for a protein of unknown function. We have …

Insoluble TATA-binding protein accumulation in Huntington's disease cortex

WMC van Roon-Mom, SJ Reid, AL Jones… - Molecular brain …, 2002 - Elsevier
Huntington's disease is a dominantly inherited neurological disorder where specific
neurodegeneration is caused by an extended polyglutamine stretch in the huntingtin protein …

Lipid composition of the brown algae Fucus vesiculosus and Ascophyllum nodosum

AL Jones, JL Harwood - Phytochemistry, 1992 - Elsevier
The lipid composition of the two brown marine algae, Fucus vesiculosus and Ascophyllum
nodosum, was very similar. The major acyl lipids were monogalactosyldiacylglycerol …

The localization and interactions of huntingtin

AL Jones - … Transactions of the Royal Society of London …, 1999 - royalsocietypublishing.org
Huntingtin was localized by using a series of antibodies that detected different areas of the
protein from the immediate N–terminus to the C–terminal region of the protein. The more C …

Lipid Metabolism in the Brown Marine Algae Fucus vesiculosus and Ascophyllum nodosum

AL JONES, JL HARWOOD - Journal of experimental Botany, 1993 - academic.oup.com
Lipid metabolism and environmental effects on this process have been studied in the marine
brown algae Fucus vesiculosus and Ascophyllum nodosum. These algae showed very …

Novel inhibitors of the condensing enzymes of the type II fatty acid synthase of pea (Pisum sativum)

AL JONES, D HERBERT, AJ RUTTER… - Biochemical …, 2000 - portlandpress.com
The type II fatty acid synthases (FASs) of higher plants (and Escherichia coli) contain three
condensing enzymes called β-ketoacyl-ACP synthases (KAS), where ACP is acyl-carrier …

Molecular investigation of TBP allele length:: A SCA17 cellular model and population study

SJ Reid, MI Rees, WMC van Roon-Mom, AL Jones… - Neurobiology of …, 2003 - Elsevier
Recently, an inherited spinocerebellar ataxia (SCA17) has been attributed to polyglutamine
coding expansions within the gene coding for human TATA-box binding protein (TBP). The …