Importance The clinical management ofBRCA1andBRCA2mutation carriers requires
accurate, prospective cancer risk estimates. Objectives To estimate age-specific risks of …

Stratification of women according to their risk of breast cancer based on polygenic risk
scores (PRSs) could improve screening and prevention strategies. Our aim was to develop …

Background Previous studies have suggested that breast cancer risk factors are associated
with estrogen receptor (ER) and progesterone receptor (PR) expression status of the tumors …

Background: Data for multiple common susceptibility alleles for breast cancer may be
combined to identify women at different levels of breast cancer risk. Such stratification could …

TERT-locus SNPs and leukocyte telomere measures are reportedly associated with risks of
multiple cancers. Using the Illumina custom genotyping array iCOGs, we analyzed∼ 480 …

Genome-wide association studies (GWAS) have identified four susceptibility loci for
epithelial ovarian cancer (EOC), with another two suggestive loci reaching near genome …

Germline BRCA1 mutations predispose to breast cancer. To identify genetic modifiers of this
risk, we performed a genome-wide association study in 1,193 individuals with BRCA1 …

Menopause timing has a substantial impact on infertility and risk of disease, including breast
cancer, but the underlying mechanisms are poorly understood. We report a dual strategy …

Ovarian cancer accounts for more deaths than all other gynecological cancers combined. To
identify common low-penetrance ovarian cancer susceptibility genes, we conducted a …

Breast cancer is the most common cancer among women. To date, 22 common breast
cancer susceptibility loci have been identified accounting for∼ 8% of the heritability of the …