The genetics of human obesity
Obesity is an important cause of morbidity and mortality in developed countries, and is also
becoming increasingly prevalent in the developing world. Although environmental factors …
becoming increasingly prevalent in the developing world. Although environmental factors …
The genetic contribution to non-syndromic human obesity
The last few years have seen major advances in common non-syndromic obesity research,
much of it the result of genetic studies. This Review outlines the competing hypotheses …
much of it the result of genetic studies. This Review outlines the competing hypotheses …
Genetics of obesity and the prediction of risk for health
AJ Walley, AIF Blakemore… - Human molecular …, 2006 - academic.oup.com
Obesity has always existed in human populations, but until very recently was comparatively
rare. The availability of abundant, energy-rich processed foods in the last few decades has …
rare. The availability of abundant, energy-rich processed foods in the last few decades has …
A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk
N Bouatia-Naji, A Bonnefond, C Cavalcanti-Proença… - Nature …, 2009 - nature.com
In genome-wide association (GWA) data from 2,151 nondiabetic French subjects, we
identified rs1387153, near MTNR1B (which encodes the melatonin receptor 2 (MT2)), as a …
identified rs1387153, near MTNR1B (which encodes the melatonin receptor 2 (MT2)), as a …
A new highly penetrant form of obesity due to deletions on chromosome 16p11. 2
Obesity has become a major worldwide challenge to public health, owing to an interaction
between the Western 'obesogenic'environment and a strong genetic contribution. Recent …
between the Western 'obesogenic'environment and a strong genetic contribution. Recent …
A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis
CC Khor, SJ Chapman, FO Vannberg, A Dunne… - Nature …, 2007 - nature.com
Toll-like receptors (TLRs) and members of their signaling pathway are important in the
initiation of the innate immune response to a wide variety of pathogens,,. The adaptor …
initiation of the innate immune response to a wide variety of pathogens,,. The adaptor …
Gene polymorphism in Netherton and common atopic disease
AJ Walley, S Chavanas, MF Moffatt, RM Esnouf… - Nature …, 2001 - nature.com
Atopic dermatitis (AD) and asthma are characterized by IgE-mediated atopic (allergic)
responses to common proteins (allergens), many of which are proteinases. Loci influencing …
responses to common proteins (allergens), many of which are proteinases. Loci influencing …
Genetic linkage of childhood atopic dermatitis to psoriasis susceptibility loci
WOCM Cookson, B Ubhi, R Lawrence, GR Abecasis… - Nature …, 2001 - nature.com
We have carried out a genome screen for atopic dermatitis (AD) and have identified linkage
to AD on chromosomes 1q21, 17q25 and 20p. These regions correspond closely with …
to AD on chromosomes 1q21, 17q25 and 20p. These regions correspond closely with …
Common nonsynonymous variants in PCSK1 confer risk of obesity
M Benzinou, JWM Creemers, H Choquet, S Lobbens… - Nature …, 2008 - nature.com
Mutations in PCSK1 cause monogenic obesity. To assess the contribution of PCSK1 to
polygenic obesity risk, we genotyped tag SNPs in a total of 13,659 individuals of European …
polygenic obesity risk, we genotyped tag SNPs in a total of 13,659 individuals of European …
Candidate DNA methylation drivers of acquired cisplatin resistance in ovarian cancer identified by methylome and expression profiling
Multiple DNA methylation changes in the cancer methylome are associated with the
acquisition of drug resistance; however it remains uncertain how many represent critical …
acquisition of drug resistance; however it remains uncertain how many represent critical …