This consensus document is intended to serve 3 functions. First, it standardizes the criteria
for diagnosis of chronic graft-versus-host disease (GVHD). Second, it proposes a new …

In HLH‐94, the first prospective international treatment study for hemophagocytic
lymphohistiocytosis (HLH), diagnosis was based on five criteria (fever, splenomegaly …

Hemophagocytic lymphohistiocytosis (HLH) is a syndrome of pathologic immune activation,
occurring as either a familial disorder or a sporadic condition, in association with a variety of …

Summary The lnterleukln-2 (IL-2) receptor y chain (IL-S&) is a component of high and
Intermediate affinity IL-2 receptors that is required to achieve full ligand binding affinity and …

Hemophagocytic lymphohistiocytosis (HLH) comprises familial (primary) hemophagocytic
lymphohistiocytosis (FHL) and secondary HLH (SHLH), both clinically characterized by …

Background The Primary Immune Deficiency Treatment Consortium was formed to analyze
the results of hematopoietic-cell transplantation in children with severe combined …

The National Marrow Donor Program (NMDP) maintains a registry of approximately 4 million
volunteer unrelated donors for patients in need of a stem cell transplant. When several …

Mutations in the LRBA gene (encoding the lipopolysaccharide-responsive and beige-like
anchor protein) cause a syndrome of autoimmunity, lymphoproliferation, and humoral …

Hemophagocytic lymphohistiocytosis (HLH) used to have a dismal prognosis. We report the
final results of HLH-94, the largest prospective diagnostic/therapeutic HLH study so far. The …

In January 1995, the Hemophagocytic Lymphohistiocytosis (HLH) Study Group opened its
first international treatment study dedicated to the hemophagocytic lymphohistiocytoses. The …