Germline mutations in BRCA1 and BRCA2 confer high risks of breast and ovarian cancer,
but the average magnitude of these risks is uncertain and may depend on the context …

Background Many cases of hereditary breast cancer are due to mutations in either the
BRCA1 or the BRCA2 gene. The histopathological changes in these cancers are often …

We analysed whole-genome sequences of 560 breast cancers to advance understanding of
the driver mutations conferring clonal advantage and the mutational processes generating …

All cancers carry somatic mutations. The patterns of mutation in cancer genomes reflect the
DNA damage and repair processes to which cancer cells and their precursors have been …

Analysis of the pattern of proteins or messengerRNAs (mRNAs) in histological tissue
sections is a cornerstone in biomedical research and diagnostics. This typically involves the …

Cancer evolves dynamically as clonal expansions supersede one another driven by shifting
selective pressures, mutational processes, and disrupted cancer genes. These processes …

Abstract Approximately 1–5% of breast cancers are attributed to inherited mutations in
BRCA1 or BRCA2 and are selectively sensitive to poly (ADP-ribose) polymerase (PARP) …

To investigate the phenotype associated with estrogen receptor α (ER) expression in breast
carcinoma, gene expression profiles of 58 node-negative breast carcinomas discordant for …

In neuroblastoma specimens, HIF-2α but not HIF-1α is strongly expressed in well-
vascularized areas. In vitro, HIF-2α protein was stabilized at 5% O 2 (resembling end …

Spatial and molecular characteristics determine tissue function, yet high-resolution methods
to capture both concurrently are lacking. Here, we developed high-definition spatial …