Linkage analysis in 16 families with incontinentia pigmenti

M Jouet; H Stewart; S Landy; J Yates; S L Yong; A Harris; C Garret; E Hatchwell; A Read; D Donnai; S Kenwrick

Linkage analysis in 16 families with incontinentia pigmenti

Eur J Hum Genet. 1997 May-Jun;5(3):168-70.

Authors

M Jouet¹, H Stewart, S Landy, J Yates, S L Yong, A Harris, C Garret, E Hatchwell, A Read, D Donnai, S Kenwrick

Affiliation

¹ Cambridge University Department of Medicine, Addenbrooke's Hospital, UK.

PMID: 9272741

Abstract

A locus for the X-linked dominant genodermatosis incontinentia pigmenti (IP) has been linked to markers in Xq28. Here we report high lod scores for markers spanning the interval DXS52-DXYS154 using 16 families, providing further evidence for a single major X-linked IP locus.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Chromosome Mapping
DNA / analysis
Female
Genetic Linkage*
Genetic Markers
Genetic Testing
Humans
Incontinentia Pigmenti / genetics*
Lod Score
Male
Pedigree
Polymorphism, Genetic
X Chromosome / genetics*

Substances

Genetic Markers
DNA