Abstract
The mouse dipeptidyl peptidase I cDNA has been cloned and sequenced and patterns of DPPI mRNA expression in various tissues characterized. Sequences encoding DPPI are highly conserved among mouse, rat and human and include an unusually long propeptide and a distinctive tyrosine adjacent to the active site cysteine.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Binding Sites
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Blotting, Northern
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COS Cells
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Cathepsin C
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Cloning, Molecular
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Conserved Sequence
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Cysteine Endopeptidases / genetics
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DNA, Complementary / genetics
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Dipeptidyl-Peptidases and Tripeptidyl-Peptidases / genetics*
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Dipeptidyl-Peptidases and Tripeptidyl-Peptidases / metabolism*
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Humans
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Mice
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Molecular Sequence Data
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Polymerase Chain Reaction
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Rats
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Recombinant Proteins / genetics
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Recombinant Proteins / metabolism
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Sequence Analysis, DNA
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Sequence Homology, Amino Acid
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Tissue Distribution
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Transfection
Substances
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DNA, Complementary
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Recombinant Proteins
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Dipeptidyl-Peptidases and Tripeptidyl-Peptidases
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Cathepsin C
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Cysteine Endopeptidases