We report the identification of a novel mouse cDNA encoding IAP38, a putative plasma membrane protein of 38 kDa in splenic macrophages, B cells and T cells. The expression of iap38 is induced by blood-stage infections of Plasmodium chabaudi malaria and is testosterone-sensitive in non-immune mice. However, when mice have acquired testosterone-resistant immunity to P. chabaudi, there is an about 40-fold increase in the expression of iap38, which has then largely lost its responsiveness to infection and testosterone. The gene iap38 is suggested to be involved in imparting spleen cells the ability to mediate testosterone-resistant immunity to P. chabaudi malaria.