Evidence for a Ras/Ral signaling cascade

L A Feig; T Urano; S Cantor

doi:10.1016/s0968-0004(96)10058-x

Evidence for a Ras/Ral signaling cascade

Trends Biochem Sci. 1996 Nov;21(11):438-41. doi: 10.1016/s0968-0004(96)10058-x.

Authors

L A Feig¹, T Urano, S Cantor

Affiliation

¹ Department of Biochemistry, Sackler School of Biomedical Sciences, Tufts University School of Medicine, Boston, MA 02111, USA. ifeig@opal.tufts.edu

PMID: 8987400
DOI: 10.1016/s0968-0004(96)10058-x

Abstract

It is becoming clear that Ras proteins mediate their diverse biological functions by binding to, and participating in, the activation of multiple downstream targets. Recent work has identified nucleotide-exchange factors for Ral-GTPases as the newest members of the set of putative Ras 'effector molecules'. This new work has also detected two potential downstream targets of Ral proteins, a novel CDC42/Rac GTPase-activating protein and a phospholipase D.

Publication types

Review

MeSH terms

Animals
Cell Cycle Proteins / metabolism*
GTP-Binding Proteins / metabolism*
Phospholipase D / metabolism*
Signal Transduction*
cdc42 GTP-Binding Protein, Saccharomyces cerevisiae
rac GTP-Binding Proteins
rap GTP-Binding Proteins
ras Proteins / metabolism*

Substances

Cell Cycle Proteins
Phospholipase D
GTP-Binding Proteins
cdc42 GTP-Binding Protein, Saccharomyces cerevisiae
rac GTP-Binding Proteins
rap GTP-Binding Proteins
ras Proteins