Abstract
ATP-driven heavy metal pumps represent a newly defined class of proteins that translocate toxic and essential metals across biological membranes. These transporters form a separate evolutionary branch of the ion-transporting P-type ATPases. We propose to call these enzymes CPx-type ATPases, based on the common novel feature of a conserved intramembranous cysteine-proline-cysteine or cysteine-proline-histidine motif.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adenosine Triphosphatases / chemistry
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Adenosine Triphosphatases / metabolism*
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Amino Acid Sequence
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Conserved Sequence*
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Humans
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Ion Pumps / metabolism*
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Metals / metabolism*
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Molecular Sequence Data
Substances
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Ion Pumps
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Metals
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Adenosine Triphosphatases
Associated data
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GENBANK/D16437
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GENBANK/J04551
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GENBANK/L06133
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GENBANK/L10909
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GENBANK/L13292
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GENBANK/L28104
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GENBANK/L33259
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GENBANK/L36317
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GENBANK/L44935
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GENBANK/M90750
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GENBANK/U00039
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GENBANK/U03434
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GENBANK/U03464
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GENBANK/U04356
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GENBANK/U08344
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GENBANK/U16658
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GENBANK/U16659
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GENBANK/U29946
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GENBANK/Z21854
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GENBANK/Z29332