Abstract
The family of ATP binding cassette (ABC) transporters or traffic ATPases is composed of several membrane-associated proteins that transport a great variety of solutes across cellular membranes. Two novel mammalian members of the family, ABC1 and ABC2, have been identified by a PCR-based approach. They belong to a group of traffic ATPases encoded as a single multifunctional protein, such as CFTR, STE 6, and P-glycoproteins. Their peculiar structural features and close relationship to ABC transporters involved in nodulation suggest that ABC1 and ABC2 define a novel subgroup of mammalian traffic ATPases.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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ATP Binding Cassette Transporter 1
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ATP-Binding Cassette Transporters / classification
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ATP-Binding Cassette Transporters / genetics*
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Adenosine Triphosphatases / classification
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Adenosine Triphosphatases / genetics*
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Amino Acid Sequence
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Animals
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Base Sequence
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Biological Transport, Active
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Chromosome Mapping
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Chromosomes, Human, Pair 9*
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Cloning, Molecular
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Cricetinae
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DNA, Complementary / genetics
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Gene Expression
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Genes
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Humans
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Membrane Proteins / genetics*
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Molecular Sequence Data
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Multigene Family*
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Polymerase Chain Reaction
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Sequence Alignment
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Sequence Homology, Amino Acid
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Tumor Cells, Cultured
Substances
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ABCA1 protein, human
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ATP Binding Cassette Transporter 1
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ATP-Binding Cassette Transporters
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DNA, Complementary
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Membrane Proteins
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Adenosine Triphosphatases
Associated data
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GENBANK/X75926
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GENBANK/X75927
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SWISSPROT/P06795
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SWISSPROT/P08716
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SWISSPROT/P21440
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SWISSPROT/P21958
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SWISSPROT/P23361
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SWISSPROT/P23703