Abstract
The deduced amino acid sequences of cDNA clones encoding human GABAA receptor alpha 1 and beta 1 subunits are presented. The human subunits display very high levels of sequence identity with the corresponding bovine receptor subunits. The cloned human GABAA receptor subunits induce the formation of GABA-gated chloride channels when expressed in mammalian cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Brain / metabolism*
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Chloride Channels
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Chlorides / physiology
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Cloning, Molecular
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DNA / genetics
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DNA / isolation & purification
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Fetus
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Humans
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Ion Channels / drug effects
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Ion Channels / physiology
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Macromolecular Substances
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Membrane Potentials / drug effects
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Membrane Proteins / physiology
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Molecular Sequence Data
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Receptors, GABA-A / genetics*
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Transfection
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gamma-Aminobutyric Acid / pharmacology
Substances
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Chloride Channels
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Chlorides
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Ion Channels
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Macromolecular Substances
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Membrane Proteins
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Receptors, GABA-A
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gamma-Aminobutyric Acid
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DNA