Lessons from the cancer genome

Levi A Garraway; Eric S Lander

doi:10.1016/j.cell.2013.03.002

Lessons from the cancer genome

Cell. 2013 Mar 28;153(1):17-37. doi: 10.1016/j.cell.2013.03.002.

Authors

Levi A Garraway¹, Eric S Lander

Affiliation

¹ Department of Medical Oncology and Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

PMID: 23540688
DOI: 10.1016/j.cell.2013.03.002

Abstract

Systematic studies of the cancer genome have exploded in recent years. These studies have revealed scores of new cancer genes, including many in processes not previously known to be causal targets in cancer. The genes affect cell signaling, chromatin, and epigenomic regulation; RNA splicing; protein homeostasis; metabolism; and lineage maturation. Still, cancer genomics is in its infancy. Much work remains to complete the mutational catalog in primary tumors and across the natural history of cancer, to connect recurrent genomic alterations to altered pathways and acquired cellular vulnerabilities, and to use this information to guide the development and application of therapies.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Animals
Genes, Neoplasm
Genome, Human
Genomics / methods*
Humans
Neoplasms / genetics*
Neoplasms / pathology
Neoplasms / therapy