Abstract
In the past fifteen years, it has become apparent that tumour-associated p53 mutations can provoke activities that are different to those resulting from simply loss of wild-type tumour-suppressing p53 function. Many of these mutant p53 proteins acquire oncogenic properties that enable them to promote invasion, metastasis, proliferation and cell survival. Here we highlight some of the emerging molecular mechanisms through which mutant p53 proteins can exert these oncogenic functions.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Gene Expression Regulation, Neoplastic
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Humans
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Molecular Targeted Therapy
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Mutant Proteins / genetics*
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Mutant Proteins / metabolism
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Mutant Proteins / physiology
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Mutation*
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Neoplasms / drug therapy
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Neoplasms / genetics*
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Protein Binding
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Protein Processing, Post-Translational
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Signal Transduction
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Transcription Factors / metabolism
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Transcription Factors / physiology
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Tumor Suppressor Protein p53 / genetics*
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Tumor Suppressor Protein p53 / metabolism
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Tumor Suppressor Protein p53 / physiology
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Tumor Suppressor Proteins / metabolism
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Tumor Suppressor Proteins / physiology
Substances
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Mutant Proteins
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TP53 protein, human
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TP63 protein, human
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Transcription Factors
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Tumor Suppressor Protein p53
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Tumor Suppressor Proteins