Defending the genome in tudor style

Godfried W van der Heijden; Alex Bortvin

doi:10.1016/j.devcel.2009.11.007

Defending the genome in tudor style

Dev Cell. 2009 Dec;17(6):745-6. doi: 10.1016/j.devcel.2009.11.007.

Authors

Godfried W van der Heijden¹, Alex Bortvin

Affiliation

¹ Department of Embryology, Carnegie Institution, Baltimore, MD 21218, USA.

PMID: 20059942
DOI: 10.1016/j.devcel.2009.11.007

Abstract

Repression of transposable elements is crucial for the survival of germ cells. In this issue of Developmental Cell, Shoji et al. provide evidence that a Tudor domain protein TDRD9 partners with MIWI2 to specifically silence LINE-1 transposons in the fetal germline of male mice.

Publication types

Comment

MeSH terms

Animals
Genome*
Male
Mice
RNA, Small Interfering / metabolism
Retroelements*
Ribonucleoproteins, Small Nuclear / chemistry
Ribonucleoproteins, Small Nuclear / metabolism*

Substances

RNA, Small Interfering
Retroelements
Ribonucleoproteins, Small Nuclear