Abstract
Lymphatic vessels have important roles in fluid homeostasis, fat absorption, inflammation and cancer metastasis and develop in a dynamic process (called lymphangiogenesis) involving budding, migration and proliferation of lymphangioblasts. Using a genetic screen in zebrafish we identify ccbe1 (collagen and calcium-binding EGF domain-1) as indispensible for embryonic lymphangiogenesis. Ccbe1 acts at the same stage of development as Vegfc and is required for lymphangioblast budding and angiogenic sprouting from venous endothelium.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Substitution
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Animals
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Binding Sites
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Calcium / metabolism
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Cell Division
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Cell Movement
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Embryo, Nonmammalian / physiology
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Embryonic Development
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Epidermal Growth Factor / genetics*
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Humans
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Lymphangiogenesis / genetics*
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Lymphatic Vessels / cytology
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Lymphatic Vessels / embryology
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Lymphatic Vessels / physiology*
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Models, Animal
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Mutation*
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Vascular Endothelial Growth Factor C / genetics
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Zebrafish
Substances
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VEGFC protein, human
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Vascular Endothelial Growth Factor C
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Epidermal Growth Factor
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Calcium