A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif

Nature. 1990 Jul 19;346(6281):240-4. doi: 10.1038/346240a0.

Abstract

A search of a 35-kilobase region of the human Y chromosome necessary for male sex determination has resulted in the identification of a new gene. This gene is conserved and Y-specific among a wide range of mammals, and encodes a testis-specific transcript. It shares homology with the mating-type protein, Mc, from the fission yeast Schizosaccharomyces pombe and a conserved DNA-binding motif present in the nuclear high-mobility-group proteins HMG1 and HMG2. This gene has been termed SRY (for sex-determining region Y) and proposed to be a candidate for the elusive testis-determining gene, TDF.

Publication types

  • Comparative Study

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Binding Sites
  • Chromosome Mapping
  • DNA / metabolism*
  • DNA Probes
  • DNA-Binding Proteins / genetics
  • Fungal Proteins / genetics
  • High Mobility Group Proteins / genetics
  • Humans
  • Male
  • Molecular Sequence Data
  • Nuclear Proteins*
  • Nucleic Acid Hybridization
  • Poly A / analysis
  • Proteins / genetics*
  • RNA / analysis
  • RNA, Messenger
  • Schizosaccharomyces / genetics
  • Sequence Homology, Nucleic Acid
  • Sex Chromosome Aberrations / genetics
  • Sex Determination Analysis*
  • Sex-Determining Region Y Protein
  • Testis / analysis
  • Testis / embryology
  • Testis / metabolism
  • Transcription Factors*
  • Y Chromosome*

Substances

  • DNA Probes
  • DNA-Binding Proteins
  • Fungal Proteins
  • High Mobility Group Proteins
  • Nuclear Proteins
  • Proteins
  • RNA, Messenger
  • SRY protein, human
  • Sex-Determining Region Y Protein
  • Transcription Factors
  • Poly A
  • RNA
  • DNA