Abstract
The abundance and size of cellular organelles vary depending on the cell type and metabolic needs. Peroxisomes constitute a class of cellular organelles renowned for their ability to adapt to cellular and environmental conditions. Together with transcriptional regulators, two groups of peroxisomal proteins have a pronounced influence on peroxisome size and abundance. Pex11-type peroxisome proliferators are involved in the proliferation of peroxisomes, defined here as an increase in size and/or number of peroxisomes. Dynamin-related proteins have recently been suggested to be required for the scission of peroxisomal membranes. This review surveys the function of Pex11-type peroxisome proliferators and dynamin-related proteins in peroxisomal proliferation and division.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Carrier Proteins
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Dynamins / physiology*
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Endocytosis / physiology
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GTP Phosphohydrolases / physiology
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GTP-Binding Proteins / physiology
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Humans
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Membrane Proteins / physiology
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Microtubule-Associated Proteins / physiology
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Mitochondria / physiology
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Mitochondrial Proteins / physiology
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Models, Biological
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Myxovirus Resistance Proteins
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Perilipin-1
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Peroxins
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Peroxisomes / physiology*
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Phosphoproteins / physiology
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Protein Isoforms / physiology
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Saccharomyces cerevisiae Proteins / physiology
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Vesicular Transport Proteins
Substances
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Carrier Proteins
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Membrane Proteins
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Microtubule-Associated Proteins
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Mitochondrial Proteins
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Myxovirus Resistance Proteins
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PEX11 protein, S cerevisiae
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Perilipin-1
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Peroxins
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Phosphoproteins
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Protein Isoforms
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Saccharomyces cerevisiae Proteins
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Vesicular Transport Proteins
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GTP Phosphohydrolases
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GTP-Binding Proteins
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VPS1 protein, S cerevisiae
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DNM1L protein, human
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Dynamins