Abstract
Heme oxygenase (HO) seems to be a novel protective factor with potent anti-inflammatory, anti-oxidant, and anti-proliferative effects. HO-1, the inducible isoform, is expressed in various tissues and is upregulated by multiple stimuli. However, humans differ quantitatively in their ability to mount an HO-1 response, modulated by two potentially functional polymorphisms in the HO-1 gene promoter region. From several studies it seems that the ability of a patient with certain genotypes to respond strongly in terms of upregulating HO-1 may be an important endogenous protective factor. In the present article we systematically review the hitherto published evidence that promoter polymorphisms in the HO-1 gene exert functional importance by influencing the level of HO-1 expression in different organ systems.
MeSH terms
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5' Untranslated Regions / genetics
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Base Sequence
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Cardiovascular Diseases / epidemiology
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Cardiovascular Diseases / genetics
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Dinucleotide Repeats
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Enzyme Induction
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Female
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Genetic Diseases, Inborn / enzymology*
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Genetic Diseases, Inborn / genetics
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Genetic Predisposition to Disease
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Genotype
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Hematologic Diseases / enzymology
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Hematologic Diseases / genetics
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Heme Oxygenase (Decyclizing) / genetics*
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Heme Oxygenase-1
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Humans
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Kidney Transplantation
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Male
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Membrane Proteins
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Molecular Sequence Data
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Nerve Degeneration / enzymology
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Nerve Degeneration / genetics
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Polymorphism, Genetic*
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Polymorphism, Single Nucleotide
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Pregnancy
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Pregnancy Complications / enzymology
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Promoter Regions, Genetic / genetics*
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Pulmonary Disease, Chronic Obstructive / epidemiology
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Pulmonary Disease, Chronic Obstructive / genetics
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Risk Factors
Substances
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5' Untranslated Regions
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Membrane Proteins
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HMOX1 protein, human
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Heme Oxygenase (Decyclizing)
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Heme Oxygenase-1