Platelet ADP receptors and their antagonists

Mini Rev Med Chem. 2003 Mar;3(2):145-8. doi: 10.2174/1389557033405412.

Abstract

ADP plays a crucial role in haemostasis and thrombosis and its receptors are potential target for antithrombotic drugs. The knowledge of the ADP-receptors has been amplified by recent discoveries. This review highlights the ADP-receptors models and their antagonists described in the recent literature, mainly the thienopyridine derivatives.

Publication types

  • Review

MeSH terms

  • Animals
  • Blood Platelets / chemistry*
  • Blood Platelets / drug effects
  • Blood Platelets / physiology
  • Fibrinolytic Agents / chemistry
  • Fibrinolytic Agents / pharmacology
  • Humans
  • Platelet Activation / drug effects
  • Platelet Aggregation Inhibitors / chemistry
  • Platelet Aggregation Inhibitors / pharmacology
  • Purinergic P2 Receptor Antagonists*
  • Pyridines / chemistry*
  • Pyridines / metabolism
  • Pyridines / pharmacology*
  • Receptors, Purinergic P2 / physiology
  • Structure-Activity Relationship

Substances

  • Fibrinolytic Agents
  • Platelet Aggregation Inhibitors
  • Purinergic P2 Receptor Antagonists
  • Pyridines
  • Receptors, Purinergic P2
  • thienopyridine