Abstract
A novel gene for Parkinson's disease (PD), DJ-1, has been identified that encodes a multifunctional product with several known protein-protein interactions and effects on gene expression. Here, I outline how it is possible to construct hypotheses that place DJ-1 in different relationships to the other known PD genes, alpha-synuclein and parkin. The identification of multiple genetic causes will provide further impetus to describe the pathway leading to PD.
MeSH terms
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Animals
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Disease Models, Animal
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Humans
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Intracellular Signaling Peptides and Proteins
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Mutation / genetics*
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Oncogene Proteins / genetics*
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Oncogene Proteins / metabolism
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Oxidative Stress / genetics*
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Parkinsonian Disorders / genetics*
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Parkinsonian Disorders / metabolism
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Parkinsonian Disorders / physiopathology
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Protein Deglycase DJ-1
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Protein Folding
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Signal Transduction / genetics*
Substances
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Intracellular Signaling Peptides and Proteins
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Oncogene Proteins
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PARK7 protein, human
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Protein Deglycase DJ-1