Abstract
The vertebrate fibroblast growth factor receptor 1 (FGFR1) is alternatively spliced generating multiple splice variants that are differentially expressed during embryo development and in the adult body. The restricted expression patterns of FGFR1 isoforms, together with differential expression and binding of specific ligands, leads to activation of common FGFR1 signal transduction pathways, but may result in distinctively different biological responses as a result of differences in cellular context. FGFR1 isoforms are also present in the nucleus in complex with various fibroblast growth factors where they function to regulate transcription of target genes.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Alternative Splicing
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Cell Nucleus / metabolism
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DNA, Complementary / metabolism
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Gene Expression Regulation, Developmental
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Humans
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Ligands
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Membrane Proteins / metabolism*
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Models, Biological
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Protein Binding
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Protein Isoforms
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Protein Structure, Tertiary
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Receptor Protein-Tyrosine Kinases / chemistry*
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Receptor Protein-Tyrosine Kinases / physiology*
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Receptor, Fibroblast Growth Factor, Type 1
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Receptors, Fibroblast Growth Factor / chemistry*
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Receptors, Fibroblast Growth Factor / physiology*
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Receptors, Notch
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Signal Transduction
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Structure-Activity Relationship
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Transcription, Genetic
Substances
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DNA, Complementary
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Ligands
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Membrane Proteins
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Protein Isoforms
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Receptors, Fibroblast Growth Factor
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Receptors, Notch
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FGFR1 protein, human
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Receptor Protein-Tyrosine Kinases
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Receptor, Fibroblast Growth Factor, Type 1