Comparative assessment of large-scale data sets of protein-protein interactions

Christian von Mering; Roland Krause; Berend Snel; Michael Cornell; Stephen G Oliver; Stanley Fields; Peer Bork

doi:10.1038/nature750

Comparative assessment of large-scale data sets of protein-protein interactions

Nature. 2002 May 23;417(6887):399-403. doi: 10.1038/nature750. Epub 2002 May 8.

Authors

Christian von Mering¹, Roland Krause, Berend Snel, Michael Cornell, Stephen G Oliver, Stanley Fields, Peer Bork

Affiliation

¹ European Molecular Biology Laboratory, Meyerhofstrasse 1, 69012 Heidelberg, Germany.

PMID: 12000970
DOI: 10.1038/nature750

Abstract

Comprehensive protein protein interaction maps promise to reveal many aspects of the complex regulatory network underlying cellular function. Recently, large-scale approaches have predicted many new protein interactions in yeast. To measure their accuracy and potential as well as to identify biases, strengths and weaknesses, we compare the methods with each other and with a reference set of previously reported protein interactions.

Publication types

Comparative Study
Evaluation Study
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Bias
Databases, Factual
False Positive Reactions
Fungal Proteins / genetics
Fungal Proteins / metabolism
Mass Spectrometry
Protein Binding
Proteins / genetics
Proteins / metabolism*
RNA, Messenger / analysis
RNA, Messenger / genetics
Reference Standards
Sensitivity and Specificity
Two-Hybrid System Techniques

Substances

Fungal Proteins
Proteins
RNA, Messenger