Linking class-switch recombination with somatic hypermutation

K Kinoshita; T Honjo

doi:10.1038/35080033

Linking class-switch recombination with somatic hypermutation

Nat Rev Mol Cell Biol. 2001 Jul;2(7):493-503. doi: 10.1038/35080033.

Authors

K Kinoshita¹, T Honjo

Affiliation

¹ Department of Medical Chemistry and Molecular Biology, Graduate School of Medicine, Kyoto University, Yoshida Konoe-cho, Sakyo-Ku, Kyoto 606-8501, Japan.

PMID: 11433363
DOI: 10.1038/35080033

Abstract

The recent discovery of a molecular link between two apparently different genetic alteration events--class-switch recombination and somatic hypermutation--has led to the idea that the recognition and cleavage of target DNA in these two events might be mediated by similar or identical molecules to those involved in RNA editing. This could mean that the complexity of mammalian genetic information may be enriched by an interplay between RNA editing and DNA modification.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

APOBEC-1 Deaminase
Animals
Cytidine Deaminase / genetics
Cytidine Deaminase / metabolism*
DNA / metabolism
Genes, Reporter
Germinal Center / immunology
Immunoglobulin Class Switching / genetics*
Models, Genetic
Mutation*
Nucleic Acid Conformation
RNA Editing
Recombinant Fusion Proteins / metabolism
Recombination, Genetic*

Substances

Recombinant Fusion Proteins
DNA
AICDA (activation-induced cytidine deaminase)
APOBEC-1 Deaminase
Cytidine Deaminase