Abstract
Mouse models of neurological abnormalities are only valuable if accurately assessed. The three-stage SHIRPA procedure is used for the standardised assessment of mouse phenotype and has been reported in a high throughput experiment in which different mutants were ascertained at one age point using stage 1 of the protocol. In this study we have validated SHIRPA using a large cohort with one single mutation, 'legs at odd angles that causes neurological dysfunction. The cohort aged from 1 to 16 months during this study and this is the first longitudinal SHIRPA analysis.
MeSH terms
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Animals
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Behavior, Animal / physiology*
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Body Weight / physiology
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Central Nervous System Diseases / congenital*
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Central Nervous System Diseases / diagnosis*
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Central Nervous System Diseases / physiopathology
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Disease Models, Animal
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Female
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Gait Disorders, Neurologic / congenital
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Gait Disorders, Neurologic / diagnosis
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Gait Disorders, Neurologic / pathology
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Genotype
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Longitudinal Studies
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Male
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Mice
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Mice, Neurologic Mutants / abnormalities*
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Mice, Neurologic Mutants / physiology
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Movement / physiology
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Phenotype
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Physical Examination / methods*
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Posture / physiology
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Psychomotor Performance / physiology
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Reproducibility of Results
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Sex Characteristics