Abstract
Maternal effect genes produce mRNA or proteins that accumulate in the egg during oogenesis. We show here that Mater, a mouse oocyte protein dependent on the maternal genome, is essential for embryonic development beyond the two-cell stage. Females lacking the maternal effect gene Mater are sterile. Null males are fertile.
MeSH terms
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Animals
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Antigens*
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Blastocyst / pathology
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Egg Proteins / genetics
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Egg Proteins / physiology*
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Embryonic and Fetal Development / genetics*
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Female
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Fetal Resorption / genetics
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Genes*
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Genomic Imprinting / genetics*
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Infertility, Female / genetics
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Leucine Zippers / genetics
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Leucine Zippers / physiology
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Mice / embryology
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Mice / genetics*
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Mice, Knockout
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Oocytes / metabolism
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Ovary / metabolism
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RNA, Messenger, Stored / genetics
Substances
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Antigens
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Egg Proteins
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Nalp5 protein, mouse
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RNA, Messenger, Stored