Phenotypes of patients with "simple" Mendelian disorders are complex traits: thresholds, modifiers, and systems dynamics

Am J Hum Genet. 2000 Jun;66(6):1729-35. doi: 10.1086/302938. Epub 2000 May 1.
No abstract available

Publication types

  • Comment
  • Editorial
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Environment
  • Genetic Diseases, Inborn / genetics*
  • Genetic Diseases, Inborn / physiopathology*
  • Genetic Variation / genetics*
  • Genotype
  • Humans
  • Models, Genetic
  • Mutation / genetics*
  • Phenotype
  • Syndrome