Single allele mutations at the heart of congenital disease

J Clin Invest. 1999 Dec;104(11):1483-4. doi: 10.1172/JCI8825.
No abstract available

Publication types

  • Comment

MeSH terms

  • Alleles
  • Animals
  • Disease Models, Animal
  • Drosophila Proteins*
  • Genetic Counseling
  • Heart / growth & development
  • Heart Defects, Congenital / genetics*
  • Heterozygote
  • Homeobox Protein Nkx-2.5
  • Homeodomain Proteins / genetics*
  • Humans
  • Mice
  • Mice, Knockout
  • Mutation*
  • Repressor Proteins / genetics
  • Trans-Activators / genetics
  • Transcription Factors*
  • Xenopus Proteins*

Substances

  • Drosophila Proteins
  • Homeobox Protein Nkx-2.5
  • Homeodomain Proteins
  • NKX2-5 protein, human
  • Nkx2-5 protein, mouse
  • Repressor Proteins
  • Trans-Activators
  • Transcription Factors
  • Xenopus Proteins
  • tin protein, Drosophila