Abstract
The sal (spalt) gene family is characterized by unique double zinc finger motifs and is conserved among various species from Drosophila to humans. Here we report a new Xenopus member of this family, Xsal-3. It is 38% homologous at the amino acid level to the previously reported Xenopus homologue of the spalt gene, Xsal-1. Alternatively spliced Xsal-3 transcripts give rise to RNAs coding either two or three double zinc fingers, and the longer form is expressed maternally. Xsal-3 is expressed in the neural tube, the mandibular, hyoid, and branchial arch, and the pronephric duct, which is different from the expression pattern of Xsal-1. These findings suggest that Xsal-3 may have distinct roles in early Xenopus development.
Copyright 1999 Academic Press.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alternative Splicing
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Amino Acid Sequence
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Animals
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Carrier Proteins / chemistry
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Carrier Proteins / genetics*
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Central Nervous System / embryology
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Central Nervous System / metabolism
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Cloning, Molecular
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Embryo, Nonmammalian / metabolism
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Intracellular Signaling Peptides and Proteins
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Mandibular Nerve / embryology
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Mandibular Nerve / metabolism
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Molecular Sequence Data
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Nerve Tissue Proteins / chemistry
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Nerve Tissue Proteins / genetics*
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Reverse Transcriptase Polymerase Chain Reaction
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Sequence Homology, Amino Acid
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Xenopus
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Xenopus Proteins*
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Zinc Fingers*
Substances
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Carrier Proteins
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Intracellular Signaling Peptides and Proteins
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Nerve Tissue Proteins
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SALL3 protein, Xenopus
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Xenopus Proteins
Associated data
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GENBANK/AB030827
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GENBANK/AB030828