Abstract
Homologs of the tumor suppressor p53, called p63 and p73, have been identified. The p63 and p73 family members possess a domain structure similar to p53, but contain variable C-terminal extensions. We find that some of the C-terminal extensions contain Sterile Alpha Motif (SAM) domains. SAM domains are protein modules that are involved in protein-protein interactions. Consistent with this role, the C-terminal SAM domains of the p63 and p73 may regulate function by recruiting other protein effectors.
MeSH terms
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Amino Acid Sequence
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Animals
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DNA-Binding Proteins / genetics*
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Genes, Tumor Suppressor
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Humans
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Membrane Proteins*
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Molecular Sequence Data
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Nuclear Proteins / genetics*
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Phosphoproteins / chemistry*
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Sequence Homology, Amino Acid
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Trans-Activators*
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Transcription Factors
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Tumor Protein p73
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Tumor Suppressor Protein p53 / chemistry*
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Tumor Suppressor Proteins
Substances
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CKAP4 protein, human
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DNA-Binding Proteins
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Membrane Proteins
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Nuclear Proteins
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Phosphoproteins
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TP63 protein, human
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TP73 protein, human
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Trans-Activators
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Transcription Factors
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Tumor Protein p73
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Tumor Suppressor Protein p53
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Tumor Suppressor Proteins